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As a polygenicdisorder, genetic studies have only started to shed light on its complex etiology.
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The data provide strong evidence for the model of Crohn's disease and ulcerative colitis as related polygenicdisorders.
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Systematic screening of the entire human genome now provides a strategy for the identification of susceptibility genes in complex polygenicdisorders.
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Neuropsychiatric disorders are highly heritable polygenicdisorders arising from the complex interplay of highly penetrant rare variants and common variants of small effect.
Usage of polygenic disease in anglès
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Osteoporosis is a polygenicdisease, whose determining loci have not yet been identified.
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Human essential hypertension is a polygenicdisease whose phenotypic expression is modulated by the environment.
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Osteoporosis is a common polygenicdisease and global healthcare priority but its genetic basis remains largely unknown.
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Genetic studies in patients and mouse models have shown that alopecia areata is a complex, polygenicdisease.
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Essential hypertension is a complex, polygenicdisease derived from the interaction of patient's genetic background with the environment.
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Consanguinity increases risk for numerous monogenic and polygenicdiseases.
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Nutritional genomics aims to prevent, treat, and manage polygenicdiseases through targeted therapies formulated from individuals' genetic makeup and dietary intake.
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If validated, GMAS may imply that common polygenicdiseases are related as much to group interactions between normal genes, as to multiple gene mutations.